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目的研究疱疹病毒感染与格要巴利综合征（ＧＢＳ）的发病的关系。方法用ＰＣＲ和ＥＬＩＳＡ方法检测４０例ＧＢＳ的血清和脑脊液中的疱次病毒及其抗体，并和其他神经系统疾病组以及正常人对照组时行比较。结果ＰＣＲ检测到２例ＧＢＳ脑脊液中有疱疹病毒存在。ＥＬＩＳＡ检测结果。ＥＬＩＳＡ检测结果：①三组脑脊液疱疹病毒ＩｇＭ全部阴性。②ＧＢＳ组２４例脑脊液中疱疹病毒ＩｇＧ阳性者麻疹病毒ＩｇＧ也全部阳性。③病人组和疾病对照组的脑脊液内疱疹病毒ＩｇＧ以及血清内疱疹病毒ＩｇＭ的阳性率差异均无显著意义（Ｐ＞００５）。结论：ＰＣＲ结果提示少数ＧＢＳ的发病与疱疹病毒有关。ＥＬＩＳＡ结果提示：格林巴利病人脑脊液中的相应的疱疹病毒抗体是非特异性的，是血脑屏障破坏所致。
Objective To study the relationship between herpes simplex virus infection and the incidence of Barre syndrome (GBS). Methods The herpes simplex virus and its antibody in serum and cerebrospinal fluid of 40 cases of GBS were detected by PCR and ELISA, and compared with other neurological disease group and normal control group. Results PCR detected herpes simplex virus in 2 GBS CSF. ELISA test results. ELISA test results: ① three groups of herpes simplex virus IgM negative. GG group of 24 cases of cerebrospinal fluid herpes virus IgG positive measles virus IgG were all positive. ③ There was no significant difference in the positive rate of CSF herpes virus IgG and herpes simplex virus IgM between the patient group and the disease control group (P> 005). Conclusion: PCR results suggest that the incidence of a few GBS is associated with herpesvirus. The ELISA results suggest that the corresponding herpesvirus antibodies in cerebrospinal fluid of patients with glaucoma are nonspecific and are due to the destruction of the blood-brain barrier.