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目的 :研究胃癌组织中生长抑素 (somatostatin ,SS)表达及其与胃癌生物学行为的关系。方法 :用免疫组化即用型SP法和核仁组织区嗜银染色法测定 5 7例胃癌及癌旁组织生长抑素的表达及细胞增殖活性。结果 :胃癌组织SS的阳性表达率为 36 8% ,癌旁为 77 2 % (P <0 0 1) ;胃窦癌SS阳性表达率为 5 0 % ,贲门癌为 19 0 % (P <0 0 1) ;分化程度好的胃癌SS阳性表达率为 5 2 2 % ,而分化程度差的胃癌为 2 6 5 % (P <0 0 1) ,即各组均有明显差异。随着各组SS表达水平的降低 ,AgNOR计数颗粒相应升高。结论 :胃癌组织中生长抑素表达与胃癌分化类型、生长部位、细胞的增殖活性有关系 ,生长抑素可能参与了胃癌细胞的增殖、分化过程
Objective: To investigate the expression of somatostatin (SS) in gastric carcinoma and its relationship with the biological behavior of gastric cancer. Methods: The somatostatin expression and cell proliferative activity in 57 cases of gastric cancer and paracancerous tissues were detected by immunohistochemistry (SP method) and argyrophilic staining of nucleolar organizer area. Results: The positive expression rate of SS in gastric cancer was 36.8% and that in adjacent tissues was 77.2% (P <0.01). The positive expression rate of SS in gastric cancer was 50% and that in cardia cancer was 190% (P <0 0 1). The positive expression rate of SS in well-differentiated gastric cancer was 52.2%, while the poorly differentiated gastric cancer was 26.5% (P <0.01), that is, there was a significant difference in each group. With the decrease of SS expression in each group, AgNOR counting particles increased accordingly. Conclusion: The expression of somatostatin in gastric cancer is related to the differentiation type, growth site and proliferative activity of gastric cancer. Somatostatin may be involved in the proliferation and differentiation of gastric cancer