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目的研究尤瑞克林对不同牛津郡社区卒中研究分型(OCSP)急性脑梗死患者神经功能的影响。方法选取我院2012年2月—2013年3月120例不同OCSP分型急性脑梗死患者,完全前循环梗死(TACI)42例、部分前循环梗死(PACI)31例、腔隙性脑梗死(LACI)26例、后循环梗死(POCI)21例。在基础治疗上采用尤瑞克林治疗。观察不同分型患者治疗前后的神经功能缺损评分(NIHSS)、治疗有效率和日常生活活动能力(Baithel)评分。结果治疗后TACI、PACI、LACI、POCI相较治疗前显著较低,具有统计学意义(P<0.05);TACI、PACI、LACI、POCI患者治疗总有效率分别为92.9%、93.5%、92.3%、95.2,四类分型治疗总有效率为93.3%;TACI、PACI、LACI、POCI患者治疗后的Baithel评分相较治疗前差异有显著性意义(P<0.05)。结论尤瑞克林对不同OCSP分型急性脑梗死患者神经功能恢复改善疗效显著,具有临床推广价值。
Objective To investigate the effect of uracil on neurological function in patients with acute cerebral infarction in community-based stroke study (OCSP) in Oxfordshire. Methods Totally 120 patients with OCSP-type acute cerebral infarction from February 2012 to March 2013 in our hospital were selected. TACI was performed in 42 cases, partial anterior circulation infarction (PACI) in 31 cases, lacunar infarction LACI) 26 cases, 21 cases of posterior circulation infarction (POCI). In the basic treatment with uricin treatment. Neurological deficit scores (NIHSS), treatment response rates, and Baithel scores before and after treatment were observed in patients with different subtypes. Results The total effective rates of TACI, PACI, LACI and POCI after treatment were significantly lower than those before treatment (P <0.05). The total effective rates of TACI, PACI, LACI and POCI were 92.9%, 93.5% and 92.3% , 95.2 respectively. The total effective rate was 93.3%. The Baithel score of TACI, PACI, LACI and POCI patients after treatment was significantly higher than that before treatment (P <0.05). Conclusion The effect of uracil on neurological recovery in patients with different OCSP subtypes of acute cerebral infarction is significant and has clinical value.