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目的探讨Bartter综合征在儿童中的临床特点及诊断与治疗。方法分析本院5例患儿的临床资料。结果Bartter综合征儿童发病,男性多见,其特点具有①水、电解质及酸碱失衡;②血清肾素、血管紧张素、醛固酮明显增高,而血压正常,③应用氯化钾、消炎痛、安体舒通等综合治疗,效果明显。结论Bartter综合征儿童中首发症状大多为多饮多尿或反复呕吐、低钾血症、低氯性代谢性碱中毒、肾素-血管紧张素Ⅱ-醛固酮明显升高。血压正常者有助于诊断与鉴别诊断。
Objective To investigate the clinical features, diagnosis and treatment of Bartter syndrome in children. Methods The clinical data of 5 children in our hospital were analyzed. Results The onset of Bartter syndrome in children was more common in males. The characteristics of them were: ① water, electrolytes and acid-base imbalance; ② serum renin, angiotensin, aldosterone were significantly increased, while blood pressure was normal; ③ potassium chloride, indomethacin, Body Shu Tong and other comprehensive treatment, the effect is obvious. Conclusions The first symptom of Bartter syndrome in children is mostly polyhydramnios or vomiting, hypokalemia, hypochlori metabolic alkalosis, renin - angiotensin Ⅱ-aldosterone was significantly increased. Normal blood pressure helps diagnosis and differential diagnosis.