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目的探讨CUE结构域2(CUE domain-containing 2,CUEDC2)表达与结直肠癌淋巴结转移的关系。方法收集2015年12月-2016年5月在我院住院手术的153例结直肠癌患者的临床资料与癌组织蜡块,使用免疫组化方法分析CUEDC2的表达,对CUEDC2与结直肠癌淋巴结转移的关系进行单因素及多因素分析。结果结直肠癌淋巴结转移患者CUEDC2免疫组化评分明显高于无淋巴结转移患者(7.41±1.46 vs 4.61±1.27,P<0.05)。多元Logistic回归分析结果表明,高CUEDC2免疫组化评分是结直肠癌发生淋巴结转移的独立危险因素。结论 CUEDC2免疫组化评分≥8分与结直肠癌淋巴结转移相关,CUEDC2可能对结直肠癌淋巴结转移起到促进作用。
Objective To investigate the relationship between CUE domain-containing 2 (CUEDC2) expression and lymph node metastasis in colorectal cancer. Methods The clinical data of 153 patients with colorectal cancer who underwent surgery in our hospital from December 2015 to May 2016 were collected. The expression of CUEDC2 was analyzed by immunohistochemistry and the relationship between CUEDC2 and lymph node metastasis of colorectal cancer The relationship between single factor and multivariate analysis. Results The immunohistochemical score of CUEDC2 in patients with lymph node metastasis of colorectal cancer was significantly higher than that of patients without lymph node metastasis (7.41 ± 1.46 vs 4.61 ± 1.27, P <0.05). Multivariate logistic regression analysis showed that high CUEDC2 immunohistochemical score was an independent risk factor for lymph node metastasis in colorectal cancer. Conclusion CUEDC2 immunohistochemical score ≥ 8 points associated with lymph node metastasis of colorectal cancer, CUEDC2 may promote lymph node metastasis of colorectal cancer.