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本文采用辣根过氧化物酶(HRP)作为抗原,与福氏佐剂一起对雄性豚鼠进行二次免疫,追踪腘淋巴结中抗体形成细胞的发育和分化。在二次免疫后的早期(2—3天),淋巴结的皮质区(特别是淋巴滤泡间区)和髓质区几乎同时出现阳性反应的细胞,主要是淡棕色的小淋巴细胞和中淋巴细胞。至6—9天,这二个区域的阳性细胞数明显增加达到高峰,主要是棕色和棕褐色的前浆细胞和浆细胞,皮质区与髓质区的阳性细胞在某些区域相连接。从12天起这二个区域的阳性细胞开始下降,在27—49天,淋巴结中只存在少数分散的阳性细胞,部分细胞萎缩变形成残留的浆细胞。在同一切片视野中除了看到棕褐色浆细胞和淡棕色小淋巴细胞外,还可以看到包括中淋巴细胞和前浆细胞等过渡型细胞。因此,我们认为浆细胞是分别在皮质区和髓质区由淋巴细胞发育而成。
In this study, horseradish peroxidase (HRP) was used as an antigen to immunize male guinea pigs with Freund’s adjuvant to track the development and differentiation of antibody-forming cells in the popliteal lymph nodes. In the early post-immunization period (2-3 days), cells that reacted positively at approximately the same time in the cortical area (especially in the lymphoid follicle area) and in the medullary area of the lymph nodes were predominantly pale brownish lymphocytes and mid-lymph nodes cell. By 6-9 days, the number of positive cells in these two regions increased significantly to peak, predominantly brown and tan plasma cells and plasma cells, and cortical and medullary areas of positive cells were connected in some areas. From the 12th day, positive cells in these two regions began to decline. Only a few scattered positive cells existed in lymph nodes between 27-49 days. Some cells atrophied to form residual plasma cells. In the same field of view in addition to see the brown plasma cells and light brown small lymphocytes, you can also see, including transitional cells such as lymphocytes and plasma cells. Therefore, we think that plasma cells are developed from lymphocytes in the cortex and medulla respectively.