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甲基莲心碱（Nef）给药后5min使豚鼠离体工作心脏的左室压（LVP）下降17.9％（P＜0.01），左室压瞬时变化速率（±dp／dt_(max))分别下降22.6％和11.7％（P均＜0.05），左室舒末压（LVEDP）上升48.6％（P＜0.01），主动脉流量（ABF）减少48.4％（P＜0.01），冠脉流量（CBF）增加10.7％（P＜0.05），心率（HR）变化不明显，Nef0.1～10.0μmol／L剂量依赖性地降低LVP、±dP／dt_(max)、ABF，而CBF在较低剂量范围内是增加的。Nef对离体豚鼠工作心脏各参数的影响类似维拉帕米。结果提示，Nef对心脏收缩性能呈剂量依赖性抑制。减少ABF，而在一定剂量范围内可增加冠脉流量。
The left ventricular pressure (LVP) of isolated guinea pig working hearts decreased by 17.9% (P<0.01) and the instantaneous rate of change of left ventricular pressure (±dp/dt_(max)) decreased 5 min after the administration of neferine (Nef). 22.6% and 11.7% (P <0.05), left ventricular end-diastolic pressure (LVEDP) increased 48.6% (P <0.01), aortic flow (ABF) decreased 48.4% (P <0.01), coronary artery flow (CBF) Increased by 10.7% (P<0.05), heart rate (HR) did not change significantly, Nef 0.1 to 10.0 μmol/L dose-dependently reduced LVP, ±dP/dt_(max), ABF, while CBF was in the lower dose range It is an increase. The effect of Nef on the parameters of isolated guinea pig working hearts is similar to verapamil. The results suggest that Nef exerts a dose-dependent inhibition of cardiac contractility. Reduce ABF and increase coronary flow within a range of doses.