我们研究肥大细胞的问题已有一百年之久,然而在很长一段时间里对它了解甚微,新近收集了大量的事实,对肥大细胞的机能等问题似乎有了比较统一的概念。肥大细胞能够释放它们的颗粒以回答多种既是物理又是化学因素的刺激,如多种阳离子、抗原抗体反应、机械或外伤的刺激,从而证明解剖学观察提供的材料是不一致的,令人混淆不清的对肥大细胞脱颗粒为分泌机能反应的观点是有争论的。这一观点似乎曾被很多生理学、生物化学以及药理学的研究所支持,在这些实验中详细的研究了肥大细胞脱颗粒的机理,但通过对照进行解剖学观察,令人确信在正常情况下是没有颗粒从细胞上脱下来的,在生物化学研究中也否定了肥大细胞脱颗粒是分泌机能的反应。试图解决这些矛盾的观点则认为脱颗粒作用可能在肥大细胞内部进行,颗粒并不释放出来,这一现象是可逆的,这是 We have been studying the issue of mast cells for a hundred years, yet we have little understanding of it for a long period of time. We have collected a large number of facts recently and seem to have a more unified concept of mast cell function and other issues. Mast cells are able to release their particles to answer a variety of stimuli that are both physical and chemical, such as multiple cations, antigen-antibody responses, mechanical or traumatic stimuli, proving inconsistent and confusing material provided by anatomical observations The unclear view that degranulation of mast cells is a secretory response is controversial. This view seems to have been supported by many physiological, biochemical, and pharmacological studies in which the mechanism of degranulation of mast cells has been studied in detail, but anatomical observation by control is convincing that under normal conditions it is No particles are detached from the cells, and in biochemical studies it is also rejected that mast cell degranulation is a secretory response. Trying to resolve these contradictions is that the degranulation may take place inside the mast cells, the particles are not released, the phenomenon is reversible, which is