垂体前叶生长激素(GH)的分泌受下丘脑两种激素调节,即生长激素释放激素(GHRH)及生长激素释放抑制激素(GHRIH,或称生长抑素SRIH)。本文简述GHRH的发现、组成、性质及临床应用。以下仅摘译其临床应用部分。 临床上给GH缺乏患者摄取GHRH,以确定有无功能性GH分泌细胞存在,这对于确定治疗方案及用药之前是必需进行的试验。作者曾将GHRH给子由于各种病因所致的身材矮小的儿童,发现那些继发于宫内生长阻滞或家族性身材矮小的儿童有正常的GH应答作用,而大多数器质性垂体功能低下 The secretion of growth hormone (GH) in the anterior pituitary is regulated by two hormones in the hypothalamus, namely growth hormone releasing hormone (GHRH) and growth hormone releasing hormone (GHRIH), or somatostatin SRIH. This article describes GHRH discovery, composition, nature and clinical application. The following only extracts its clinical application part. GHRH is clinically ingested by GH-deficient patients to determine the presence or absence of functional GH-secreting cells, a test necessary to determine the regimen and administration. The authors gave GHRH to children with short stature due to various causes and found that those with secondary to intrauterine growth retardation or familial stature had normal GH response and that most of the organic pituitary function low