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目的探讨5-氟尿嘧啶(5-Fu)与双嘧达莫(DPM)作用对肾癌细胞生长的影响。方法以人肾癌细胞系(RCC925)为研究对象,运用长春新硷(VLB；Velban)作为参照的有/无核苷酸体外条件培养体系来研究不同浓度5-Fu(0．6、6．0、60．0 mg/L)与DPM的作用。结果当DPM浓度不变时,不同浓度5-Fu(0．6、6．0、60．0mg/L)分别对应的肾癌细胞生长抑制率组间比较差异有统计学意义(P＜0．05)；当5-FU浓度不变时,不同浓度DPM(0、1．25、2．50、5．00、10．00mg/L)分别对应的肾癌细胞生长抑制率组间比较差异有统计学意义(P＜0．05)；而且6、60mg/L浓度的5- Fu与5mg/L DPM联合应用,与单用0．078mg/L VLB对肾癌细胞的生长抑制率比较差异有统计学意义(P＜0．05)。结论5-Fu与DPM联合应用可优化肾癌治疗。
Objective To investigate the effects of 5-fluorouracil (5-Fu) and dipyridamole (DPM) on the growth of renal cell carcinoma. Methods Human renal cancer cell line (RCC925) was used as a research object to study the effects of different concentrations of 5-Fu (0.6,6. 0, 60.0 mg / L) and DPM. Results When the concentration of DPM was constant, the growth inhibition rates of renal cancer cells with different concentrations of 5-Fu (0.6, 6.0 and 60.0 mg / L) were significantly different (P <0. 05). When the concentration of 5-FU was constant, the growth inhibition rate of renal cancer cells with different concentrations of DPM (0,1.25,2.50,5.00,10.00 mg / L) (P <0.05). Moreover, the combination of 5- Fu with 6, 60mg / L and 5mg / L DPM showed a significant difference compared with the single use of 0.078mg / L VLB Statistical significance (P <0.05). Conclusion The combination of 5-Fu and DPM can optimize the treatment of renal cell carcinoma.