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目的评价大分割适形放射治疗对腹膜后软组织肿瘤术后患者的治疗作用。方法对1998年10月2003年4月收治的16例腹膜后软组织急性肿瘤术后患者行大分割适形放射治疗,设计临床靶区等效生物剂量为55～62Gy,观察放疗后2、5年局部控制率、生存率和无病生存情况。结果 2、5年局部控制率较未行放疗患者明显提高并和其他放射治疗方式达到较高治疗剂量者近似;远期生存无改善,无病生存率较未行放疗患者有提高。结论大分割适形放射治疗方式对腹膜后软组织急性肿瘤术后患者有较好的局部控制作用,无瘤生存率有提高,远期生存无改善,无严重的远期放疗后遗症。
Objective To evaluate the therapeutic effect of large segmental conformal radiotherapy on postoperative patients with retroperitoneal soft tissue tumors. Methods Totally 16 patients with acute retroperitoneal soft tissue tumors treated with large-dose conformal radiotherapy from October 1998 to April 2003 were enrolled in this study. The equivalent biological dose for clinical target area was designed to be 55 ~ 62Gy. After 2 and 5 years of radiotherapy Local control rate, survival rate and disease-free survival. Results The local control rates at 2 and 5 years were significantly higher than those without radiotherapy and were similar to those of other radiotherapy modalities. The long-term survival did not improve, and the disease-free survival rate was higher than that of patients without radiotherapy. Conclusions Large split conformal radiotherapy has a better local control effect on postoperative patients with acute retroperitoneal soft tissue tumor. The survival rate of the patients with retroperitoneal soft tissue is improved, the long-term survival is not improved, and there is no serious long-term radiological sequelae.