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目的 为了探讨脑梗死 (CI)患者与胰岛素抗体 (IAb)及胰岛素抗性 (IR)的关系。方法 采用放射免疫法 ,测定 50例脑梗死与 30例脑动脉硬化 (AS)及正常对照组血浆IAb及IR。结果 CI及AS血浆IAb阳性率明显高于对照组 ,且脑梗死伴高血压者血浆IAb明显高于单纯脑梗死组。CI、AS患者存在明显胰岛素抵抗 ,且脑梗死伴高血压组与单纯脑梗死比较 ,其IR更明显。结论 IAb、IR参与了CI、AS的发病过程 ,IR可能是CI及AS的独立危险因素
Objective To investigate the relationship between insulin resistance (IAb) and insulin resistance (IR) in patients with cerebral infarction (CI). Methods Radioimmunoassay was used to determine plasma IAb and IR in 50 patients with cerebral infarction and 30 patients with cerebral arteriosclerosis (AS) and normal control group. Results The positive rate of IAb in CI and AS plasma was significantly higher than that in control group, and the plasma IAb in cerebral infarction with hypertension was significantly higher than that in simple cerebral infarction group. CI, AS patients with significant insulin resistance, and cerebral infarction with hypertension compared with simple cerebral infarction, the IR more obvious. Conclusion IAb and IR are involved in the pathogenesis of CI and AS. IR may be an independent risk factor for CI and AS