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目的 利用计算机和图像、信号采集设备建立冠状动脉阻抗系统 ,并研究冠状动脉阻抗参数的稳定性。方法 与心电信号同步通过腔内超声导管、多普勒导丝和压力导丝 ,获取随心动周期变化的冠状动脉腔内超声图像、流速和压力信号 ;通过自制软件得到随心动周期变化的腔内面积曲线、平均流速曲线、压力曲线和流量 /压力曲线 ;按机电类比方法通过傅立叶变换得到冠脉阻抗参数。采集不同情况下 1 0头小型猪以及 2 1例病人左前降支的基础状态和最大充血状态重复性测量信号分别为 80对。结果 相关分析发现重复性冠脉阻抗参数间有很好的相关性 (P <0 .0 1 ) ;基础状态和充血状态的平均冠脉阻抗和一次谐波冠脉阻抗的决定系数 (r2 )均大于0 .97(P <0 .0 0 1 )。结论 本实验成功建立反映冠脉脉动流阻力的冠脉阻抗系统 ,其中平均冠脉阻抗和一次谐波冠脉阻抗有很高的稳定性
Objective To establish a coronary impedance system using computer and image and signal acquisition equipment and to study the stability of coronary impedance parameters. Methods The intracavitary ultrasound images, flow velocity and pressure signals were obtained by intracardiac ultrasound catheter, Doppler guide wire and pressure guide wire synchronously with the ECG signal. The cavity with the cardiac cycle was obtained by home-made software The inner area curve, the average flow curve, the pressure curve and the flow / pressure curve. The impedance parameters of the coronary artery were obtained by Fourier transform according to the method of electromechanical analogy. The basic status of the left anterior descending branch and the maximum congestive state repeatability measurement signals of 10 piglets in different situations and 80 cases were collected respectively. Results Correlation analysis showed that there was a good correlation between parameters of repetitive coronary impedance (P <0.01). The average coronary impedance and the determinant coefficient of first harmonic coronary impedance (r2) both in basal state and congestive state Greater than 0 .97 (P <0 .0 0 1). Conclusion This experiment successfully established a coronary impedance system reflecting coronary flow resistance, in which the average coronary impedance and the first harmonic coronary impedance have a high stability