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在合成抗胆碱药物1-苯基-1-坏戊基-2-(3-托品基)-乙烯等一类化合物时,将相应的叔醇在冰乙酸-盐酸中脱水,产率均在90%左右,但当以2-吡咯基替代环戊基时,在相同条件下脱水,由于吡咯环遇酸不稳定,易发生聚合和氧化,使反应物变成黑色粘稠物,结果未能成功。后分别选用吡啶-氯化亚砜,碘-二甲苯作脱水剂,亦未得到预期的乙烯化合物。文献曾报道,用碘化甲基三苯基磷(MTPI)的六甲基磷酰胺(HMPA)溶液能使
In the synthesis of anticholinergic drugs such as 1-phenyl-1 -deopentyl-2- (3-trophyl) -ethylene and the like, the corresponding tertiary alcohols were dehydrated in glacial acetic acid-hydrochloric acid at a yield of 90 %, But when using 2-pyrrolyl instead of cyclopentyl, under the same conditions of dehydration, due to acid pyrrole instability, prone to polymerization and oxidation, the reaction becomes a black sticky, the result failed . After the selection of pyridine - thionyl chloride, iodine - xylene dehydration agent, nor the expected ethylene compounds. It has been reported in literature that hexamethylphosphoramide (HMPA) solution of methyltriphenylphosphonium iodide (MTPI)