论文部分内容阅读
目的:探讨直肠癌组织中血管内皮细胞生长因子-C(VEGF-C)与CEA、Survivin表达的关系及其对直肠癌临床病理特征和预后的判定价值。方法:应用SP免疫组织化学方法检测VEGF-C、CEA和Survivin 3种蛋白在82例直肠癌组织及30例癌旁正常组织中的表达,分析它们与直肠癌病理学特征的关系,以及VEGF-C与CEA、Survivin的相关性。结果:直肠癌组织中VEGF-C与CEA、Survivin阳性表达率分别为45.1%、56.1%和47.6%。癌旁组织中Survivin蛋白表达率为5.0%,VEGF-C和CEA蛋白阳性表达率分别为10.5%和14.0%;直肠癌组织中VEGF-C表达与CEA表达呈正相关(r=0.287,P=0.024),与Survivin表达呈正相关,r=0.320,P=0.018。VEGF-C与CEA、Survivin的表达与TNM分期差异均有统计学意义(P<0.05),与年龄、性别、肿块大小及病理分型差异均无统计学意义,P>0.05。结论:VEGF-C与CEA、Survivin在直肠癌患者中高表达;其均与直肠癌的浸润、转移有关,三者联合检测可用于直肠癌的病期程度和预后判断的参考,可能对直肠癌的预后评估有一定的临床意义。
Objective: To investigate the relationship between the expression of vascular endothelial growth factor-C (VEGF-C) and CEA and Survivin in rectal cancer and to evaluate the clinicopathological features and prognosis of rectal cancer. Methods: The expression of VEGF-C, CEA and Survivin in 82 rectal cancer tissues and 30 adjacent normal tissues was detected by SP immunohistochemistry. The relationship between VEGF-C, CEA and Survivin in pathological features of rectal cancer and the relationship between VEGF- C and CEA, Survivin correlation. Results: The positive rates of VEGF-C, CEA and Survivin in rectal cancer tissues were 45.1%, 56.1% and 47.6% respectively. The positive rates of Survivin protein and VEGF-C and CEA protein were 5.0% and 14.0% respectively. The positive rates of VEGF-C and CEA in rectal cancer tissues were significantly higher than those in normal tissues (r = 0.287, P = 0.024 ), Which was positively correlated with Survivin expression (r = 0.320, P = 0.018). There was significant difference between the expression of VEGF-C, CEA, Survivin and TNM staging (P <0.05), but no significant difference with age, sex, tumor size and pathological type, P> 0.05. CONCLUSIONS: The expression of VEGF-C, CEA and Survivin in rectal cancer patients are highly correlated with the invasion and metastasis of rectal cancer. The combined detection of VEGF-C and CEA and Survivin may be used as reference for the stage and prognosis of rectal cancer. Prognostic assessment has some clinical significance.