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巯甲丙脯酸为治疗高血压病与心衰的常用药物,分子结构类似D-青霉胺,1981年起国外已有人用于类风湿性关节炎(RA)的治疗。我们自1985年起用此药治疗RA病人15例,效果满意,现报告如下。一、治疗对象均为女性,平均年龄51.3岁(24～63岁),≥50岁的有10例。平均病程5年(1～15年)。诊断依据美国风湿病协会(ARA)的RA诊断标准,病情活动性参考Martin等的指标,即都有6个以上关节触痛;有3个以上关节肿胀;晨僵都在45分钟以上;血沉(ESR)均>30mm;C反应蛋白(CRP)阳性等。二、治疗方法服用巯甲丙脯酸前,停服
Captopril is a commonly used drug for the treatment of hypertension and heart failure. Its molecular structure is similar to that of D-penicillamine. Since 1981, it has been used in the treatment of rheumatoid arthritis (RA) in other countries. We have used this medicine since 1985, the treatment of RA patients in 15 cases, the results are satisfactory, are as follows. First, the treatment of patients are female, the average age of 51.3 years (24 to 63 years old), ≥ 50 years old in 10 cases. The average duration of 5 years (1 to 15 years). Diagnosis based on RA diagnostic criteria of the American College of Rheumatology (ARA), disease activity reference Martin and other indicators, which have more than 6 joint tenderness; more than 3 joint swelling; morning stiffness are more than 45 minutes; ESR ESR)> 30mm; C-reactive protein (CRP) -positive. Second, the treatment before taking captopril, stop taking