目的:探讨中性粒细胞对淋巴细胞比值(N/L比值)与晚期胃癌临床病理特点的关系。方法:收集2004年4月至2007年8月间的293名TNM III,IV期行手术治疗的胃癌病例的临床病理资料,结合N/L比值进行分析。N/L比值通过术前血常规检查中性粒细胞和淋巴细胞计数计算得出。结果:高NLR组IV期病例,R2切除和联合脏器切除的比例更高,肿瘤直径更大,差别具有显著性(P=0.017,0.007,0.001),而年龄,伴随疾病,肿瘤部位,Bormann分型,病理分级,Lauren分型,淋巴血管侵犯和术后化疗情况在两组间无明显差异。N/L比值在III,IV期胃癌病例中差别具有显著性(P=0.018)。结论:术前N/L比值跟晚期胃癌分期,手术根治程度相关,N/L比值升高提示分期偏晚。N/L比值可以作为一个简单可信的预后指标用来指导胃癌术后风险评估和治疗选择。 Objective: To investigate the relationship between the ratio of neutrophils to lymphocytes (N / L ratio) and the clinicopathological features of advanced gastric cancer. Methods: The clinical data of 293 TNM III and IV gastric cancer patients who underwent surgery between April 2004 and August 2007 were collected, and their N / L ratios were analyzed. The N / L ratio was calculated by preoperative blood tests for neutrophil and lymphocyte counts. Results: In the high NLR group, the proportion of patients with stage IV, R2 resection and combined organ resection was higher, the tumor diameter was larger, the difference was significant (P = 0.017,0.007,0.001), while the age, concomitant disease, tumor site, Bormann There was no significant difference between the two groups in the classification, pathological grade, Lauren classification, lymphatic vessel invasion and postoperative chemotherapy. The N / L ratio was significantly different between cases III and IV of gastric cancer (P = 0.018). Conclusions: The preoperative N / L ratio is related to the stage of advanced gastric cancer and the degree of radical operation. The higher N / L ratio suggests that the stage is late. N / L ratio can be used as a simple and reliable prognostic indicator to guide postoperative gastric cancer risk assessment and treatment options.