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目的:用Meta分析评价NQO1基因C609T多态性与结直肠癌易感性关系。方法:检索知网、万方等数据库,收集符合要求的文献,计算合计的OR值及95%可信区间,并评估发表偏倚。结果:杂合基因型CT和突变纯合基因型TT均增加结直肠癌的发病风险。亚洲人携带CT和TT基因型是结直肠癌的危险因素;以医院为基础的病例对照研究中携带CT和TT基因型是结直肠癌的危险因素。结论:携带CT和TT基因型个体发生结直肠癌的风险增高。
OBJECTIVE: To evaluate the relationship between the C609T polymorphism of NQO1 gene and susceptibility to colorectal cancer by Meta-analysis. Methods: The databases of Zhifang, Wanfang and so on were searched, and the documents which meet the requirements were collected. The total OR and 95% confidence intervals were calculated and the publication bias was evaluated. Results: Heterozygous genotype CT and mutant homozygous genotype TT all increased the risk of colorectal cancer. Asians carrying CT and TT genotypes are risk factors for colorectal cancer; hospital-based case-control studies carrying CT and TT genotypes are risk factors for colorectal cancer. Conclusion: The individuals with CT and TT genotypes have an increased risk of developing colorectal cancer.