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细胞增殖必伴有染色体的一分为二及细胞质的增生，β微管蛋白则参与细胞的增殖过程．正性和负性调节因子对β微管蛋白的表达及细胞增殖间的相关性研究显示，不同生理剂量的正性调节因子ＩＧＦⅡ、Ｔ３／Ｔ４处理ＵＭＲ１０６细胞１２ｈ，Ｎｏｒｔｈｅｒｎｂｌｏｔ实验发现它们在促进细胞ＤＮＡ合成的同时，可使β微管蛋白ｍＲＮＡ表达增加，呈剂量依赖关系．而负性调节因子ＴＮＦα则相反地在抑制细胞ＤＮＡ合成的同时，使β微管蛋白ｍＲＮＡ表达降低，也呈剂量依赖关系．Ｗｅｓｔｅｒｎｂｌｏｔ实验进一步表明，ＩＧＦⅡ可使β微管蛋白表达增加，而ＴＮＦα使β微管蛋白表达降低．由此可见，β微管蛋白的合成与细胞增殖间存在着一定的相互联系．
Cell proliferation must be accompanied by chromosomes in two and cytoplasmic hyperplasia, beta tubulin is involved in the proliferation of cells. Positive and negative regulatory factors on the expression of β-tubulin and cell proliferation between the correlation study showed that different physiological doses of the positive regulator IGF Ⅱ, T3 / T4 UMR106 cells treated 12h, Northern blot found that they are in promoting cell DNA Synthesis at the same time, can make β tubulin mRNA expression increased in a dose-dependent manner. The negative regulatory factor TNFα, on the contrary, inhibits the synthesis of DNA in the cell while reducing the expression of β-tubulin mRNA in a dose-dependent manner. Westernblot experiments further showed that IGF II increased the expression of beta tubulin, while TNF alpha reduced the expression of beta tubulin. Thus, β tubulin synthesis and cell proliferation there is a certain interrelationship.