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目的观察应用卡铂联合化疗过程中患者肾功能的变化。方法选择术后接受卡铂联合化疗方案的卵巢癌患者７例，共观察２６个疗程。于化疗中每周应用彩色多普勒超声仪监测患者肾脏血流，测定肾脏中心区域的区域动脉、叶间动脉的血流速度波形，求得收缩期最高血流速度（Ｖｍａｘ），扩张期最低血流速度（Ｖｍｉｎ）及阻力指数。同时对１４例正常妇女测定以上相应指标（对照组）。结果化疗第１～３周，肾血流速度与对照组比较下降显著（Ｐ＜０．０１）；肌酐清除率（Ｃｃｒ）随扩张期Ｖｍｉｎ下降而显著下降（ｒ＝０．５２，Ｐ＜０．０１）。结论应用卡铂联合化疗，可引起肾功能障碍。肾脏血流速度能反映肾功能变化，可作为一项监测指标。
Objective To observe the changes of renal function in patients undergoing carboplatin combined with chemotherapy. Methods Seven patients with ovarian cancer who underwent carboplatin combined with chemotherapy were selected for a total of 26 courses of treatment. Weekly color Doppler ultrasound was used to monitor the renal blood flow during chemotherapy. The blood flow velocity waveforms in the regional arteries and interlobar arteries in the central region of the kidney were measured to obtain the maximum systolic blood flow velocity (Vmax) and the minimum expansion time. Blood flow velocity (Vmin) and resistance index. At the same time, the corresponding indicators (control group) were determined for 14 normal women. Results Compared with the control group, the renal blood flow velocity decreased significantly (P<0.01) during the first 3 weeks of chemotherapy; the creatinine clearance rate (Ccr) decreased significantly with the decrease of the expansion phase Vmin (r=0.52, P<0). .01). Conclusion Carboplatin combined with chemotherapy can cause renal dysfunction. Renal blood flow velocity can reflect changes in renal function and can be used as a monitoring indicator.