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如所周知,关于烧伤后蛋白质分解代谢的机理已有过广乏地研究,但是对于这些反应的精确的激素调节问题迄今未予阐明。已发现在一些分解代谢状态下(如饥饿、糖尿病、严重感染及创伤等)血浆高血糖素水平和胰岛素相比是过高的。这提示上述两种激素可能参与分解代谢的调节。作者欲阐明这两种激素在烧伤病员的分解代谢中有何意义。作者观察了11名男性热烧伤病人,烧伤前都无糖尿病病史。入院后头168小时内首次取血样,而后间隔不同时间取血样,直至病员康复或死亡。分别测量血样中高血糖素(glucagon),胰岛素,葡萄糖及尿素含量。
As is well known, the mechanism of protein catabolism after burn has been extensively studied, but the exact hormone regulation of these reactions has so far not been elucidated. It has been found that in some catabolic states (such as starvation, diabetes, severe infections, trauma, etc.) plasma glucagon levels are excessively high compared to insulin. This suggests that the above two hormones may be involved in the regulation of catabolism. The authors wish to elucidate the significance of these two hormones in the catabolism of burn patients. The authors looked at 11 men who had a thermal burn and had no history of diabetes before they were burned. Blood samples were collected for the first time within 168 hours after admission, then blood samples were taken at different intervals until the patients recovered or died. The levels of glucagon, insulin, glucose and urea in blood samples were measured respectively.