论文部分内容阅读
目的探讨供者脾细胞对同种异体心脏移植免疫耐受的诱导效果 ,为抗排斥反应治疗提供依据。方法分别采用供者脾细胞 (SPC)和环磷酰胺 (CP)预处理移植受者 ,然后行大鼠异位心脏移植术 ,根据实验分组对移植心脏存活情况进行观察。结果对照组、CP组和 SPC组移植心脏的存活时间分别为 7.2 1± 2 .5 6 d、9.78± 2 .5 5 d和 15 .14± 8.5 6 d,经统计学处理后证实 ,3组移植心脏的存活时间有显著性差异 (P<0 .0 5 )。结论供者脾细胞预处理移植受体 ,可以明显地延长大鼠同种异体心脏移植的存活时间。
Objective To investigate the effect of donor spleen cells on immune tolerance of allogeneic heart transplantation and to provide basis for anti-rejection therapy. Methods Transplanted recipients were pretreated with donor spleen cells (SPC) and cyclophosphamide (CP) respectively, and then subjected to ectopic heart transplantation in rats. The survival of transplanted hearts was observed according to the experimental grouping. Results The survival time of heart transplantation in control group, CP group and SPC group were 7.21 ± 2.56d, 9.78 ± 2.55d and 15.14 ± 8.56d, respectively. After statistical analysis, the survival time in group 3 There was a significant difference in survival time of transplanted heart (P <0.05). Conclusions Donor spleen cells pretreatment of transplant recipients can significantly prolong the survival time of allogeneic heart transplantation in rats.