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目的分析血浆D-二聚体水平与血小板聚集功能在反复自然流产患者中的诊断价值。方法 102例反复自然流产患者为观察组,对其血浆D-二聚体水平与血小板聚集功能进行检测,另选取100例健康妇女(无自然流产史、非孕期)为对照组,对两组进行对比。结果观察组患者血浆D-二聚体中位值为0.27 mg/L,对照组中位值为0.15 mg/L,比较差异具有统计学意义(P<0.05)。两组二磷酸腺苷(ADP)诱导血小板凝集率异常比较差异无统计学意义(P>0.05),D-二聚体水平异常比较差异具有统计学意义(P<0.01)。结论反复自然流产患者血小板处于高凝状态,对血浆D-二聚体水平与血小板聚集功能进行检测,具有临床诊断价值,为疾病的进一步治疗提供一定参考价值。
Objective To analyze the diagnostic value of plasma D-dimer and platelet aggregation in patients with recurrent spontaneous abortion. Methods A total of 102 patients with recurrent spontaneous abortion were enrolled in the study. Plasma D-dimer and platelet aggregation were measured. 100 healthy women (no history of spontaneous abortion and non-pregnancy) were selected as the control group, Compared. Results The median plasma D-dimer was 0.27 mg / L in the observation group and 0.15 mg / L in the control group. The difference was statistically significant (P <0.05). There was no significant difference in ADP-induced platelet aggregation rate (P> 0.05). The difference of D-dimer level between the two groups was statistically significant (P <0.01). Conclusions Platelet in patients with recurrent spontaneous abortion is in hypercoagulable state, and the plasma D-dimer level and platelet aggregation function are detected, which has clinical value in diagnosis and provides some reference value for further treatment of the disease.