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患者为29岁女性,1974年3月因下肢进行性轻瘫痪6周就诊。作椎板切除术时,发现从椎间隙突出一丛L_3～L_5的浸润性包块,未能完全切除,组织学证实为淋巴瘤,术后局部接受了3,500γ的放射治疗,除仍有轻瘫外,其余良好。至7月中旬,颈部及主动脉旁淋巴结肿大,上纵隔阻塞,肝脾肿大。复查组织学证实恶性淋巴瘤(免疫母细胞性、弥散性),且有浸润生长的特征。8月用COP方案(环磷酰胺1g、长春新硷2mg静注,继以强的松每日40mg分次服用7日),每4周重复一疗程。在化疗的第2日患者心率从70～80次/分减至35次/分,且不规则。心电图证实为房性心动过速伴4:1～8:1房室传导阻滞,ST段及
The patient was a 29-year-old woman who had 6 weeks of mild paralysis due to lower limbs in March 1974. For laminectomy, it was found that a bundle of L_3 ~ L_5 infiltrative mass protruding from the intervertebral space, failed to completely resected, histologically confirmed as lymphoma, postoperative local accepted 3,500γ radiation therapy, in addition to still light Paralyzed, the rest is good. To mid-July, neck and aortic lymph nodes, obstruction of the mediastinum, hepatosplenomegaly. Reexamination of histologically confirmed malignant lymphoma (immunoblastic, diffuse), and invasive growth characteristics. August with COP program (cyclophosphamide 1g, vincristine 2mg intravenous injection, followed by prednisone 40mg daily sub-day taking 40mg), repeated every 4 weeks course of treatment. On the second day of chemotherapy, the heart rate was reduced from 70 to 80 beats per minute to 35 beats per minute, and irregular. ECG confirmed as atrial tachycardia with 4: 1 ~ 8: 1 atrioventricular block, ST segment and