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目的:探讨广东汉族妇女p21基因多态性与尖锐湿疣易感性的关系。方法:提取88例HPV16和/或HPV18阳性的尖锐湿疣患者和95例健康对照者的静脉血DNA,分别用RELP的方法检测p21基因型,比较各基因型检出率的差别;并比较不同基因型患者在临床表型方面的差异。结果:患者组Ser/Ser及Ser/Arg的检出率高于健康对照组;皮疹无论为扁平角化样还是乳头瘤样均以Ser/Ser及Ser/Arg的检出率为高。结论:编码Ser的基因可能是尖锐湿疣的易感基因。
Objective: To investigate the relationship between the polymorphism of p21 gene and the susceptibility of condyloma acuminatum in Han women of Guangdong. Methods: The venous blood DNA of 88 patients with HPV16 and / or HPV18 positive condyloma acuminatum and 95 healthy controls were extracted. The p21 genotypes were detected by RELP method, and the differences of the detection rates of different genotypes were compared. Type of patients in the clinical phenotype differences. Results: The detection rate of Ser / Ser and Ser / Arg in patients was higher than that in healthy controls. The detection rate of Ser / Ser and Ser / Arg in both rash were flattened or rash. Conclusion: The gene encoding Ser may be a susceptibility gene for condyloma acuminatum.