作者从1970年起对120例类风湿性关节炎患儿应用免疫抑制剂治疗。年龄3—15岁,其中60例应用瘤可宁(Leuceran)治疗并追踪观察7—10年。30例病程达8年多,以重度多关节型为主。关节内脏型患儿常以Still’s综合征起病,波及许多内脏,以急性或亚急性、轻度或重度病变入院。有14例对肾上腺皮质素有依赖性,其病情继续进展。瘤可宁开始剂量为0.1—0.2 mg/kg日,每日 From 1970 onwards 120 cases of rheumatoid arthritis in children with immunosuppressive therapy. Aged 3-15 years of age, 60 of them were treated with Leuceran and followed up for 7 to 10 years. 30 cases of the course of more than 8 years, mainly with severe multi-joint type. Joint visceral children often onset of Still’s syndrome, involving many internal organs, to acute or subacute, mild or severe disease hospitalization. There are 14 cases of dependence on the adrenal cortex, the disease continues to progress. Tumor Ning starting dose of 0.1-0.2 mg / kg day, daily