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目的 :探讨细胞色素P450(cytochrome P450 proteins,CYP)1A1*2C基因多态性与儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)易感性的关系。方法 :计算机检索Pub Med、Embase、Ovid数据库、中国期刊全文数据库、中国生物医学文献数据库、中国知网和万方数据库,收集CYP1A1*2C多态性与儿童ALL易感性的相关病例-对照研究,应用STATA 12.0软件进行Meta分析,计算合并比值比(odds ratio,OR)及95%可信区间(coni dence intervals,CI),并进行亚组分析。结果:共纳入7篇符合要求的病例-对照研究。Meta分析结果显示,CYP 1A 1*2C多态性与儿童ALL发生风险相关[G vs A(OR=1.20,95%CI:1.01~1.43);GG vs AA(OR=1.73,95%CI:1.11~2.70);GG vs AG+AA(OR=1.68,95%CI:1.09~2.59)]。根据对照来源进行亚组分析,结果显示,对照来源于和病例组同期住院的患者(hospital-based case-control,HCC)的基因型[G vs A(OR=1.29,95%CI:1.04~1.59)、GG vs AA(OR=1.89,95%CI:1.15~3.10)和GG vs AG+AA(OR=1.83,95%CI:1.14~2.94)]与儿童ALL易感性相关。敏感性分析剔除异质性较大的研究后,各基因模型与儿童ALL易感性无关,各亚组分析结果亦无统计学相关性。结论 :C YP1A1*2C多态性可能与儿童ALL易感性无关。
Objective: To investigate the relationship between the polymorphisms of cytochrome P450 proteins (CYP) 1A1 * 2C and the susceptibility to childhood acute lymphoblastic leukemia (ALL). Methods: The case-control study on CYP1A1 * 2C polymorphism and susceptibility to childhood ALL was collected from PubMed, Embase, Ovid database, Chinese Journal Full-text Database, Chinese Biomedical Literature Database, China Knowledge Network and Wanfang Database. Meta-analysis was performed using STATA 12.0 software to calculate odds ratio (OR) and 95% confidence interval (CI), and subgroup analyzes were performed. Results: A total of 7 eligible case-control studies were included. Meta-analysis showed that the CYP 1A 1 * 2C polymorphism was associated with the risk of childhood ALL [G vs A (OR = 1.20, 95% CI: 1.01-1.43; GG vs AA (OR = 1.73, 95% CI: 1.11 ~ 2.70); GG vs. AG + AA (OR = 1.68, 95% CI: 1.09-2.59)]. A subgroup analysis based on control sources showed that the controls were genotyped from hospital-based case-control (HCC) patients in the same period [G vs A (OR = 1.29, 95% CI: 1.04 to 1.59 ), GG vs AA (OR = 1.89, 95% CI: 1.15 to 3.10) and GG vs AG + AA (OR = 1.83, 95% CI: 1.14 to 2.94) Sensitivity analysis Excluding the heterogeneity of the larger study, the genetic model has nothing to do with the susceptibility of children with ALL, sub-group analysis of the results are not statistically significant. Conclusion: C YP1A1 * 2C polymorphism may not be related to the susceptibility of children with ALL.