在离体大鼠主动脉条上,观察纤维蛋白(原)降解产物肽6A灌流对血管反应性及血管组织cGMP含量的影响。结果表明,肽6A呈剂量依赖地显著扩张离体血管,其作用在去内皮后消失;肽6A还能显著提高离体血管组织cGMP含量,NO合成抑制剂L-NNA可阻断这一作用。NO前体L-精氨酸可逆转L-NNA的效应。提示,肽6A可通过促进血管内皮释放内皮舒张因子而扩张血管。 On the aortic strips of isolated rat, effects of peptide 6A perfusion of fibrin (prot) degradation product on vascular reactivity and cGMP content in blood vessels were observed. The results showed that peptide 6A significantly dilate isolated blood vessels in a dose-dependent manner, and disappeared after removing the endothelium. Peptide 6A also significantly increased cGMP content in isolated vascular tissue, and L-NNA, an inhibitor of NO synthesis, blocked this effect. NO precursor L-arginine reverses the effect of L-NNA. It is suggested that peptide 6A can dilate blood vessels by promoting the release of endothelial relaxing factor by vascular endothelium.