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大鼠注射0.25％氟化钠溶液1～6毫升/千克体重持续到16～30天时,产生典型的慢性氟中毒。大于此剂量时,皆有急性氟中毒发生。慢性氟中毒时,大鼠切牙出现黄白相间的斑釉条纹;纵断磨片在光学显微镜下有釉质暗带;软X线检查,暗带有透射现象;偏光显微镜检查此暗带呈正光性双折射。牙本质也有相应改变。除牙齿外,牙槽骨和股骨也有钙化紊乱现象。慢性氟中毒的程度与氟化物的种类、剂量以及动物的年龄、进入体内的钙离子等因素有关。
Rats injected with 0.25% sodium fluoride solution 1 to 6 ml / kg body weight continued to 16 to 30 days, resulting in a typical chronic fluorosis. Greater than this dose, there are acute fluorosis occurred. Chronic fluorosis, the rat incisors appeared yellow and white spot glaze stripes; longitudinal grinding disc under the light microscope enamel dark zone; soft X-ray examination, dark with transmission phenomenon; polarized light microscopy was positive Birefringence. Dentin has also changed accordingly. In addition to teeth, alveolar bone and femur also have calcification disorders. The degree of chronic fluorosis is related to the type and amount of fluoride, the age of the animal, and the amount of calcium ions that enter the body.