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目的 :探讨异基因造血干细胞移植后并急性移植物抗宿主病 (aGVHD)的特点及有效防治。方法 :2例 (急性粒细胞白血病、急性粒单细胞白血病各 1例 )采用改良的马利兰、环磷酰胺方案进行预处理后 ,输注供者骨髓血或外周血干细胞。1例 (慢性粒细胞白血病 )予马法兰 +阿糖胞苷 +环磷酰胺 +足叶乙甙方案预处理 ,回输外周血干细胞。aGVHD的预防均用环胞菌素A、甲氨蝶呤 ,出现GVHD后加用甲基强的松龙治疗。结果 :移植后均获造血重建 ,发生较为严重的aGVHD 2例。结论 :联合各种免疫抑制剂 ,能有效防治GVHD ,使患者获得长期造血重建
Objective: To investigate the characteristics and effective prevention and treatment of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation. Methods: Two cases (acute myeloid leukemia and acute myelomonocytic leukemia in one case) were treated with a modified malayan and cyclophosphamide regimen and then infused donor bone marrow blood or peripheral blood stem cells. One case (chronic myelogenous leukemia) was treated with melphalan + cytarabine + cyclophosphamide + etoposide solution and the peripheral blood stem cells were transfused. Prevention of aGVHD with cyclosporin A, methotrexate, GVHD plus methylprednisolone treatment. Results: Two cases of aGVHD with severe hematopoietic reconstitution occurred after transplantation. Conclusion: Combined with various immunosuppressive agents, can effectively prevent and treat GVHD, so that patients receive long-term hematopoietic reconstitution