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目的 :比较羟基喜树碱、噻 口替哌、丝裂霉素和卡介苗共 4种药物各自膀胱灌注预防膀胱肿瘤复发的疗效。方法 :不同药物均加入 5 0ml生理盐水内经尿道灌注入膀胱 ,术后第 1个月每周灌注 1次 ,以后每月灌注 1次达2年。结果 :羟基喜树碱组的无肿瘤复发率和 1年无病率明显高于其他组 (P <0 .0 1) ,而复发率则明显低于其他组(P <0 .0 1) ,且副作用小。结论 :羟基喜树碱为腔内灌注预防膀胱肿瘤复发的良好药物
OBJECTIVE: To compare the curative effect of urinary camptothecin, thiophanate-piperazine, mitomycin and BCG in preventing the recurrence of bladder tumor by urinary bladder instillation. Methods: Different drugs were added into the bladder via the urethra 50ml normal saline, the first month after surgery perfusion once a week, after a monthly perfusion once for 2 years. Results: The recurrence rate and 1-year disease-free rate in hydroxycamptothecin group were significantly higher than those in other groups (P0.01), but the relapse rate was significantly lower than that in other groups (P0.01) And side effects. CONCLUSION: Hydroxycamptothecin is a good drug for preventing the recurrence of bladder tumor by intraluminal infusion