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目的 :探讨用地塞米松联合异烟肼治疗胸膜炎的临床效果。方法 :对2012年9月~2014年9月期间我院收治的30例胸膜炎患者的临床资料进行回顾性研究。将这30例患者随机分为对照组和观察组,每组各有15例患者。对两组患者均使用2SHRZ/4HR抗结核方案进行治疗,将两组患者的胸腔积液抽出后再向其中注射药物,为对照组患者注入10mg的地塞米松,为观察组患者注入10mg的地塞米松+0.3g的异烟肼。然后,比较两组患者的治疗效果及其不良反应的发生率。结果 :观察组患者治疗的总有效率明显高于对照组患者,二者相比差异具有显著性(p<0.05,X2=4.261)。观察组患者不良反应的发生率明显高于对照组患者,二者相比差异具有显著性(p<0.05,x2=1.623)。结论 :为胸膜炎患者注入地塞米松+异烟肼进行治疗的效果比为其单纯注入地塞米松进行治疗的效果好,但用地塞米松+异烟肼对患者进行治疗的不良反应发生率较高。因此,应根据患者的实际情况,为其选择合适的方法进行治疗。
Objective: To investigate the clinical effect of dexamethasone combined with isoniazid in the treatment of pleurisy. Methods: The clinical data of 30 patients with pleurisy admitted in our hospital from September 2012 to September 2014 were retrospectively studied. The 30 patients were randomly divided into control group and observation group, each with 15 patients. Both groups were treated with anti-TB 2SHRZ / 4HR regimen. The pleural effusion was withdrawn from both groups and then injected into the two groups. 10 mg of dexamethasone was injected into the control group and 10 mg to the observation group Dexamethasone + 0.3 g of isoniazid. Then, the treatment effect and the incidence of adverse reactions in both groups were compared. Results: The total effective rate of observation group was significantly higher than that of the control group, the difference was significant (p <0.05, X2 = 4.261). The incidence of adverse reactions in the observation group was significantly higher than that in the control group, the difference was significant (p <0.05, x2 = 1.623). CONCLUSION: Dexamethasone + isoniazid is effective in patients with pleuritis compared with those treated with dexamethasone alone, but patients treated with dexamethasone + isoniazid have a higher incidence of adverse events . Therefore, patients should be based on the actual situation, choose the appropriate method for treatment.