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胰腺癌是恶性程度较高的肿瘤,早期诊断困难。microRNAs(miRNAs)由19～23个核苷酸所组成的小分子单链RNA。miRNAs属基因负调控因子,可在转录后水平调控靶基因的表达,从而影响肿瘤细胞的发育、分化和凋亡等。近年研究发现,胰腺癌组织、细胞株、癌前病变和血浆中均存在miRNAs表达谱异常,提示miRNAs可能在胰腺癌发生和发展机制的研究、诊断、治疗和预后判断中具有一定应用价值。本文就相关研究进展作一综述。
Pancreatic cancer is a more malignant tumor, early diagnosis difficult. MicroRNAs (miRNAs) Small, single-stranded RNA consisting of 19 to 23 nucleotides. MiRNAs are gene negative regulatory factors that regulate the expression of target genes at the post-transcriptional level, thereby affecting tumor cell development, differentiation and apoptosis. Recent studies have found that miRNAs expression abnormalities exist in pancreatic cancer tissue, cell lines, precancerous lesions and plasma, suggesting that miRNAs may have some value in the study of pancreatic cancer occurrence and development mechanism, diagnosis, treatment and prognosis. This article reviews the progress of related research.