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目的观察1%盐酸特比奈芬乳膏治疗浅部真菌病疗效及安全性。方法以克霉唑霜为对照,采用随机对照临床试验方法治疗浅部真菌病160例,其中特比奈芬组80例,克霉唑组80例。患者随机接受1%盐酸特比奈芬乳膏和克霉唑霜治疗,均为每日2次。治疗结束后根据临床症状、体症、真菌镜检和培养评价临床疗效。结果1%盐酸特比奈芬乳膏总有效率为91.2%;克霉唑霜总有效率为80.0%;真菌清除率1%盐酸特比奈芬乳膏为85.0%,克霉唑霜为71.3%。两种药物对改善患者症状体征均有效,1%盐酸特比奈芬乳膏疗效优于克霉唑霜(P<0.05)。结论1%盐酸特比奈芬乳膏治疗浅部真菌病疗效好、安全性好。
Objective To observe the efficacy and safety of 1% terbinafine cream in the treatment of superficial fungal diseases. Methods Clotrimazole cream was used as a control. 160 cases of superficial mycosis were treated by randomized clinical trial. Among them, 80 were treated with terbinafine and 80 with clotrimazole. Patients were randomized to receive 1% Terbinafine Hydrochloride Cream and Clotrimazole Cream, both twice daily. After treatment, according to clinical symptoms, physical disease, fungal microscopy and culture evaluation of clinical efficacy. Results The total effective rate of 1% terbinafine hydrochloride cream was 91.2%, the total effective rate of clotrimazole cream was 80.0%, fungi clearance rate of 1% terbutaline hydrochloride cream was 85.0% and clotrimazole cream was 71.3%. Both drugs are effective in improving symptoms and signs of patients, 1% terbinafine hydrochloride cream is superior to clotrimazole cream (P <0.05). Conclusion 1% terbinafine hydrochloride cream for the treatment of superficial mycosis has good efficacy and good safety.