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本文报道我院65例口服氨茶碱患者血药浓度监测结果。小儿5mg/kg/次一日三次组21例;成人100mg 一日三次组24例,200mg 一日三次组20例。其茶碱平均稳态血浆浓度分别为10.56±6.67g/uml,7.85±3.96ug/ml 及14.93±10.25ug/ml。9例(14%)出现毒副反应。作者对给药方法与血药浓度及毒副反应的关系进行讨论,有助于临床合理用药。
This article reports 65 cases of oral aminophylline in our hospital plasma concentration monitoring results. 21 cases of pediatric 5mg / kg / time three times a day; 24 cases of adult 100mg three times a day, 200mg three times a day group of 20 cases. The theophylline average steady-state plasma concentrations were 10.56 ± 6.67g / uml, 7.85 ± 3.96ug / ml and 14.93 ± 10.25ug / ml. Nine patients (14%) had toxic side effects. The author discusses the relationship between drug delivery methods and plasma concentration and toxicity, which is helpful for clinical rational drug use.