卵巢早衰(POF)是生殖医学的一大难题,卵子形成与发育的任一环节受损都有可能导致POF。POF的病因复杂多样,其中遗传因素目前认为是最主要的原因,而环境因素近几年越来越受到重视。能被病因诊断的POF患者极少,大量研究专注于寻找POF形成的相关基因。改善低雌激素引起的症状,尽可能恢复患者生育功能是POF的主要治疗原则。 Premature ovarian failure (POF) is a major problem in reproductive medicine, POF can be caused by any damage of egg formation and development. The causes of POF are complex and diverse, of which the genetic factors are currently considered to be the most important reason, and environmental factors have drawn more and more attention in recent years. There are very few cases of POF that can be diagnosed by etiology, and a large number of studies have focused on finding relevant genes for POF formation. Improve the symptoms caused by low estrogen, as far as possible to restore the patient’s reproductive function is the main treatment POF principle.