目前世界上约有150万妇女采用合成性孕激素注射剂作为长效避孕剂,为了深入了解这类药物的作用机理,作者对使用最普遍的两种孕激素制剂—醋甲孕酮(medroxy—Progesterone acet-ate,MPA)和庚酸炔诺酮(norethisterone—oenanthate,NET-e)的抗促性腺作用加以研究。另外还研究MPA和NET-e与一些哺乳类动物循环中激素结合球蛋白的结合,及其与大鼠下丘脑和垂体细胞内甾体激素受体的结合。本组研究包括5例绝经后妇女(下称PMW)和3例睾丸女性化综合征患者(下称TFS)。经 Currently, about 1.5 million women in the world use synthetic progestin injections as long-acting contraceptives. To gain insight into the mechanism of action of these agents, the authors used medroxy-Progesterone acet-ate, MPA) and norethisterone-oenanthate (NET-e). In addition, the binding of MPA and NET-e to hormone-binding globulin in some mammalian circulations and their association with steroid hormone receptors in rat hypothalamus and pituitary cells were also studied. This study included 5 cases of postmenopausal women (PMW) and 3 cases of testicular feminization syndrome (TFS). through