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正性肌力药物(IA)可增强心肌收缩力,改善循环功能,减轻心力衰竭的症状,作为辅助治疗,短期应用确有较好效果.但慢性心力衰竭患者长期使用IA则不然,从理论上来看,至少存在以下四方面潜在危害性.一、增加心肌能耗IA使肥厚的心脏作功增加,能耗也随之增加.若能耗超过衰竭心脏提供高能磷酸盐的能力,IA可加速心肌细胞坏死,甚至加速患者死亡(见于缺血性心脏病以及长期负荷过重的心肌病和瓣膜病).
Inotropic agents (IA) can enhance myocardial contractility, improve circulatory function, reduce the symptoms of heart failure, as an adjuvant therapy, short-term use does have a good effect. However, long-term use of IA in patients with chronic heart failure is not, theoretically To see, at least the following four potential hazards: First, to increase myocardial energy IA to hypertrophy of the heart to do work, energy consumption also increases.If energy consumption exceeds the failure of the heart to provide high-energy phosphate capacity, IA can accelerate myocardial Cell necrosis, and even accelerated patient death (see ischemic heart disease and long-term overweight cardiomyopathy and valvular disease).