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目的探讨干扰素α-2b对早孕合并细菌性阴道病(bacterial vaginal disease,BV)绒毛血管超微结构及滋养细胞血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响。方法将泸州医学院附属医院门诊就诊的早孕合并BV要求终止妊娠妇女25例作为治疗组,予以重组人干扰素α-2b栓10万IU/d治疗共5 d;选取同期正常早孕妇女30例作为对照组。评价干扰素α-2b治疗的临床疗效;并应用透射电镜观察绒毛血管超微结构及免疫组化链酶素抗生物蛋白—过氧化物酶连接(streptavidinperosidase,SP)法检测绒毛滋养细胞VEGF的表达水平。结果治疗组临床疗效评价有效率为84%;透射电镜观察到治疗组绒毛血管超微结构改变较对照组无明显差别(P>0.05);两组滋养细胞VEGF的表达水平差异无统计学意义(P>0.05)。结论干扰素α-2b治疗早孕合并BV有效,未发生绒毛血管的异常改变。
Objective To investigate the effects of interferon α-2b on the villus ultrastructure and the expression of vascular endothelial growth factor (VEGF) in early pregnancy complicated with bacterial vaginal disease (BV). Methods 25 cases of pregnant women with termination of pregnancy who were treated by the outpatient clinic of Affiliated Hospital of Luzhou Medical College were enrolled as the treatment group and treated with recombinant human interferon α-2b suppositories for 10 days at a dose of 100000 IU / d for 30 days. Thirty normal pregnant women Control group. The clinical efficacy of interferon α-2b was evaluated. The ultrastructure of villus and the expression of VEGF in villous trophoblasts were detected by streptavidin perosidase (SP) Level. Results The effective rate of clinical curative effect evaluation in treatment group was 84%. There was no significant difference in ultrastructure of villus of treated group compared with control group (P> 0.05) by transmission electron microscopy. There was no significant difference in the expression of VEGF between the two groups P> 0.05). Conclusion Interferon α-2b treatment of early pregnancy combined with BV effective, no abnormal changes in the villus.