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山莨菪碱(654-2)是临床常用的抗休克药物,但其作用机理尚不清楚。多数学者认为654-2通过扩张血管治疗休克。本文比较654-2与α-受体阻断剂酚苄明(Phenoxybenzamine,POB)对家兔感染性休克的疗效,以探讨654-2的抗休克机理。 材料和方法 2.0～2.5公斤雄兔,在1％普鲁卡因局麻下作下腹正中切口。在盲肠上穿绕一粗线绳,线头引出腹壁外,用8号针头在穿线近端盲肠无血管部位刺12个小
Anisodamine (654-2) is a commonly used clinical anti-shock drugs, but its mechanism of action is not yet clear. Most scholars believe that 654-2 through the dilation of blood vessels to treat shock. This article compared the efficacy of 654-2 and the alpha-blocker phenoxybenzamine (POB) on septic shock in rabbits to investigate the anti-shock mechanism of 654-2. Materials and Methods Male rabbits weighing 2.0-2.5 kg were given a median abdominal incision under 1% procaine local anesthesia. In the cecum wound around a thick rope, the thread leads to the abdominal wall, with a No. 8 needle in the proximal cecum of the threading of the non-vascular site stab 12 small