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Hyun Kul Lee 等人发现大黄水物提对 T_A 菌株具有抑菌作用和诱变作用,但未发现抗诱变作用。同时又证明了用苯、醇等溶剂所得的大黄提取物只有抑菌作用而无诱变作用。作者等对该抗诱变有效的大黄水提物的化学成分进行了研究,以期阐述其生长抑制、诱变和抗诱变的可分性,并为进一步论证药效与成分的关系提供量的依据。本文报道了化学研究的初步结果。实验材料CS—930双波长色谱扫描仪日本岛津1.8-二羟蒽醌西德 Marck 公司硅胶 G(10～40μ),青岛海洋化工厂试剂均为 AR 级
Hyun Kul Lee et al. found that rhubarb water extract had antibacterial and mutagenic effects on T_A strains, but no antimutagenic effect was found. At the same time, it was proved that the rhubarb extracts obtained with solvents such as benzene and alcohol had only antibacterial effect but no mutagenic effect. The authors studied the chemical constituents of the rhubarb aqueous extract effective against this mutagenesis in order to expound its growth inhibition, mutagenesis, and mutagenic separability, and provide evidence for further demonstrating the relationship between efficacy and composition. in accordance with. This article reports preliminary results of chemical research. Experimental material CS-930 Dual-wavelength Chromatography Scanner Shimadzu, Japan 1.8-Hydroxythione Marck Silicone G (10～40μ), Qingdao Ocean Chemical Factory reagents are all AR grades