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本研究评价冠心病病人接受经皮冠状动脉腔内成形术(PTCA)及心脏病发作致短暂心肌缺血时心房利钠因子(ANF)的释放。 29例病人稳定型单支冠状动脉病变并有心绞痛症状(加拿大心血管协会Ⅱ～Ⅲ级)分为三组。A组11例(男 8,女 3;年龄58.6±1.4岁)单支血管施行 PTCA,球囊扩张 90～120秒,反复测量平均肺动脉楔压(MPAWP)并从肺动脉取血测定ANF(基础值及PTCA后 2、5、15分钟的值)。B组 10例(男 6,女4;年龄 51.5±2.1岁)为对照,染料负荷血管造影在15分钟内完成,在0、10、15、30、45、60分钟测定 MPAWP和 ANF。C组 8例(男5,女3;年龄 52.1±2.2岁)于心绞痛发作时,5(胸痛即将解除时)、10、15、30分钟测定
This study evaluated the release of atrial natriuretic factor (ANF) in patients with coronary artery disease undergoing percutaneous transluminal coronary angioplasty (PTCA) and transient myocardial ischemia following heart attack. 29 patients with stable single coronary artery disease and angina pectoris (Canadian Cardiovascular Society Ⅱ ~ Ⅲ grade) were divided into three groups. In group A, 11 patients (8 males, 3 females, age 58.6 ± 1.4 years) underwent PTCA with balloon dilation for 90-120 seconds. Mean pulmonary artery wedge pressure (MPAWP) was measured repeatedly and blood was taken from the pulmonary artery to measure ANF And 2,5,15 minutes after PTCA). Group B, 10 (male 6, female 4; age 51.5 ± 2.1 years) as a control, dye-loaded angiography within 15 minutes, and MPAWP and ANF at 0, 10, 15, 30, 45, 60 minutes. Eight patients in group C (male 5, female 3; age 52.1 ± 2.2 years) developed angina pectoris, 5 (when chest pain was about to be released), 10, 15, and 30 minutes