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目的:探讨黄酮类化合物水飞蓟宾(SB)对阿霉素(Dox)所致小鼠心肌毒性的影响,为临床上防护Dox毒性提供依据。方法:以Dox处理的昆明种小鼠为模型,测定预先给予SB的小鼠血清肌酸激酶(CK)、谷草转氨酶(AST)活性以及心脏丙二醛(MDA)含量变化。结果:SB可拮抗Dox所致CK、AST活性升高,并能降低心脏MDA含量。结论:SB能明显减少Dox诱发的心肌脂质过氧化物的形成,从而显著减轻其心脏毒性。
Objective: To investigate the effect of flavonoid silybin (SB) on cardiotoxicity in mice induced by doxorubicin (Dox), and to provide a basis for clinical protection of Dox toxicity. Methods: The Dox-treated Kunming mice were used as the model to determine the changes of serum creatine kinase (CK), aspartate aminotransferase (AST) activity and the content of malondialdehyde (MDA) in the heart of the mice pretreated with SB. Results: SB could antagonize the increase of CK and AST induced by Dox and decrease the content of MDA in the heart. Conclusion: SB can significantly reduce the Dox-induced myocardial lipid peroxide formation, thereby significantly reducing its cardiotoxicity.