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目的:探讨黄酮类化合物作为DNA拓扑异构酶Ⅱ抑制剂以及孕期黄酮类化合物摄入与婴幼儿白血病间的关系。方法:应用PubMed、万方和维普科技期刊数据库检索系统,以“黄酮类化合物、白血病和拓扑异构酶Ⅱ抑制剂”为关键词,检索1987-01-2012-09的相关文献,共检索到英文文献7条,中文文献0条,以任意2个关键词搜索,共检索到英文文献1 445条,中文文献108条。纳入标准:1)黄酮类化合物的基本资料介绍。2)婴幼儿白血病的基本资料介绍。3)拓扑异构酶及拓扑异构酶Ⅱ抑制剂的基本资料介绍。4)拓扑异构酶Ⅱ抑制剂与白血病的关系。5)黄酮类化合物与婴幼儿白血病的关系。根据纳入标准精选46篇文献,最后纳入分析32篇。结果:黄酮类化合物广泛存在于日常食物中,对人类健康有许多积极作用。但是,黄酮类化合物作为拓扑异构酶Ⅱ抑制剂也存在遗传毒性、细胞毒性,某些实体瘤患者在应用DNA拓扑异构酶Ⅱ抑制剂治疗后可继发白血病,其细胞遗传学异常多与原发急性髓系白血病(AML)有关,其中最常见的是位于染色体11q23的混合系白血病(MLL)基因异位。孕期黄酮类化合物摄入与婴幼儿某种类型白血病的发生风险增高有一定的关系。在急性婴幼儿白血病患者中,>80%都包括位于染色体11q23的MLL基因异位或异常重组。样本量均超过200例的5个病例对照研究显示,孕期摄入大量含DNA拓扑异构酶Ⅱ抑制剂的食物(主要为含黄酮类化合物的水果和蔬菜等)后,MLL重排引起的AML的发病风险增高。结论:了解黄酮类化合物作为DNA拓扑异构酶Ⅱ抑制剂以及孕期黄酮类化合物摄入与婴幼儿白血病间的关系,有助于孕妇膳食指导及膳食指南的修订与完善。
OBJECTIVE: To investigate the relationship between flavonoids as DNA topoisomerase Ⅱ inhibitor and flavonoid intake during pregnancy and infant leukemia. Methods: Using the PubMed, Wanfang and VIP databases to search the key words of “flavonoids, leukemia and topoisomerase Ⅱ inhibitors”, the related literatures of 1987-01-2012-09 were searched for There were 7 English documents and 0 Chinese documents. There were 1 445 English articles and 108 Chinese articles retrieved by any 2 key words. Inclusion criteria: 1) Introduction of basic information on flavonoids. 2) Infant infant leukemia basic information introduced. 3) Introduction of topoisomerase and topoisomerase II inhibitors. 4) the relationship between topoisomerase Ⅱ inhibitor and leukemia. 5) flavonoids and infant leukemia relationship. A total of 46 literatures were selected based on the inclusion criteria, and finally 32 were included in the analysis. Results: Flavonoids are widely distributed in daily food and have many positive effects on human health. However, as a topoisomerase Ⅱ inhibitor, flavonoids are also genotoxic and cytotoxic. Some patients with solid tumors may be secondary to leukemia after treatment with DNA topoisomerase Ⅱ inhibitors. The cytogenetic abnormalities are associated with Primary acute myeloid leukemia (AML), the most common of which is the heterologous leukemia (MLL) gene on chromosome 11q23. There is a certain relationship between the intake of flavonoids during pregnancy and the increased risk of certain types of leukemia in infants and young children. In acute infantile leukemia,> 80% includes the abnormal or abnormal recombination of the MLL gene located on chromosome 11q23. Five case-control studies, each with a sample size of more than 200, showed that MLL rearrangement-induced AML during pregnancy after ingestion of large amounts of food containing DNA topoisomerase II inhibitors (mainly flavonoid-containing fruits and vegetables, etc.) The incidence of increased risk. Conclusion: It is helpful to understand the relationship between flavonoids as DNA topoisomerase Ⅱ inhibitor and the intake of flavonoids during pregnancy and infant leukemia. It is helpful for the dietary guidance and dietary guidelines for pregnant women to be revised and improved.