论文部分内容阅读
目的:研究白藜芦醇固体脂质纳米粒(resveratrol-solid lipid nanopartieles,Res-SLN)对H22移植性肿瘤模型小鼠的肿瘤抑制作用。方法:将昆明种小鼠接种肝癌H22瘤株造成相应的移植性荷瘤小鼠模型后,随机分为荷瘤模型组、环磷酰胺(CTX)阳性药对照组(25 mg.kg-1),Res-SLN低、中、高(35,70,105 mg.kg-1)3个剂量组、白藜芦醇(resveratrol,Res)混悬液组(105 mg.kg-1)、空白辅料组,以实体瘤模型小鼠的瘤重、抑瘤率观察Res-SLN对小鼠移植性肿瘤H22的抑制作用;以胸腺指数、脾脏指数为指标观察Res-SLN对免疫器官的影响;以小鼠平均生存时间观察Res-SLN对腹水瘤模型小鼠的生命延长作用。结果:Res-SLN能有效地抑制实体瘤模型荷瘤小鼠体内肿瘤的生长,低、中、高3个剂量组的抑瘤率分别为61.95%,72.39%,85.52%;Res-SLN给药组小鼠胸腺指数和脾脏指数与荷瘤对照组相比,无显著性差异;Res-SLN中、高剂量组对腹水瘤肿瘤模型小鼠的生存时间具有延长作用,与荷瘤对照组相比具显著性差异。结论:Res-SLN对荷瘤小鼠肿瘤生长具有一定的抑制作用,抑制作用强于Res,并有剂量依赖性。
Objective: To study the tumor inhibitory effect of Resveratrol-solid lipid nanopartieles (Res-SLN) on H22 transplanted tumor model mice. Methods: Kunming mice were inoculated with H22 tumor cell lines to induce the corresponding transplanted tumor-bearing mouse models and then randomly divided into tumor-bearing model group, cyclophosphamide (CTX) positive control group (25 mg.kg-1) , Resveratrol (Res) suspension group (105 mg.kg-1), blank adjuvant group, The inhibitory effect of Res-SLN on the transplanted tumor H22 was observed by the tumor weight and tumor inhibition rate in solid tumor model mice. The effects of Res-SLN on immune organs were observed by using thymus index and spleen index. Survival time To observe the life-extending effect of Res-SLN on ascites tumor model mice. Results: Res-SLN could effectively inhibit tumor growth in solid tumor-bearing mice. The tumor inhibition rates of Res-SLN were 61.95%, 72.39% and 85.52%, respectively. Res-SLN There was no significant difference in the thymus index and spleen index between the mice and the tumor-bearing control group. The medium and high dose groups of Res-SLN could prolong the survival time of the ascitic tumor model mice compared with the tumor-bearing control group A significant difference. Conclusion: Res-SLN can inhibit the tumor growth of tumor-bearing mice to a certain extent, and its inhibitory effect is stronger than that of Res. The dose-dependent manner.