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目的探讨孕中期唐氏征筛查检查中AFP、Free-β-HCG、uE3中位数倍数(MOM)结果与胎儿染色体异常及其他先天畸形的关系。方法回顾性分析2009.1-2010.1在我院接受孕中期唐氏征筛查并成功随访的4250例单胎孕妇血清学筛查MOM(multiples of median)值结果与胎儿染色体异常及其他畸形发生情况。结果在4250例孕妇中,共筛查出有MOM值异常404例,其中染色体异常7例,神经管缺陷及其他畸形14例。血清学MOM值正常孕妇中发现21-三体1例,其他胎儿畸形13例,两组比较,胎儿染色体异常及其他畸形发生率有显著差距。结论孕中期血清学筛查指标MOM值异常对胎儿染色体异常,神经管缺陷及其他先天异常的发现均有一定的预测价值。
Objective To explore the relationship between AFP, Free-β-HCG, median of uE3 (MOM) and fetal chromosomal abnormalities and other congenital malformations during the second trimester of pregnancy screening. Methods The results of MOM (multiples of median) value of 4250 singleton pregnancies pregnant women receiving screening of Down’s syndrome during the second trimester of pregnancy in our hospital from January 2009 to October 2010,1 were retrospectively analyzed and the incidence of fetal chromosomal abnormalities and other deformities were analyzed. Results Among 4250 pregnant women, 404 cases of MOM abnormalities were screened out, including 7 cases of chromosomal abnormalities, 14 cases of neural tube defects and other deformities. Serum MOM normal pregnant women found in 21 cases of trisomy 1, 13 cases of other fetal malformations, two groups, fetal chromosomal abnormalities and other deformities were significantly different. Conclusion Abnormal MOM values in the second trimester of pregnancy may have some predictive value for the detection of fetal chromosomal abnormalities, neural tube defects and other congenital abnormalities.