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目的探究8种临床常用抗菌药物对鲍曼不动杆菌的体外抗菌活性以及含舒巴坦制剂药物的体外联合抗菌活性,为临床治疗鲍曼不动杆菌提供联合用药的实验依据。方法耐药鲍曼不动杆菌30株,采用微量肉汤稀释法测定8种临床常用抗菌药物及阿米卡星与头孢哌酮钠/舒巴坦钠、哌拉西林/舒巴坦、美洛西林/舒巴坦联合用药的最低抑菌浓度。结果 8种临床常用抗菌药物中带有舒巴坦制剂的抗生素对鲍曼不动杆菌显示一定的体外抗菌活性,三代头孢都表现为强耐药;阿米卡星与头孢哌酮钠/舒巴坦钠联合后联合抑菌指数小于1,表现为协同相加作用,哌拉西林/舒巴坦,美洛西林/舒巴坦分别有5%和30%联合抑菌指数大于1,表现为无关作用。结论鲍曼不动杆菌对临床常用抗菌药物已经产生了很强的耐药性,临床可优先选择阿米卡星或带舒巴坦制剂的抗生素,也可根据患者具体情况选用联合进行治疗,以防耐药株的产生和医院感染的扩散,并注意消毒与隔离,防止交叉感染。
OBJECTIVE To investigate the in vitro antibacterial activity of eight commonly used antibacterial agents against Acinetobacter baumannii and the in vitro antibacterial activity of the drugs containing sulbactam and to provide experimental basis for clinical treatment of Acinetobacter baumannii. Methods The drug-resistant Acinetobacter baumannii 30 strains were determined by micro broth dilution method. The eight commonly used antibacterial drugs and amikacin and cefoperazone sodium / sulbactam sodium, piperacillin / sulbactam, mezlocillin / Shu The minimum antibacterial concentration of the combination of tuberculosis. Results The antibiotics with sulbactam in eight clinical antibacterials showed some in vitro antibacterial activity against Acinetobacter baumannii, and the third generation cephalosporins showed strong resistance. Amikacin combined with cefoperazone sodium / sulbactam sodium After combined inhibition index of less than 1, the performance of the synergistic addition, piperacillin / sulbactam, mezlocillin / sulbactam 5% and 30% respectively, the combined antibacterial index greater than 1, showed irrelevant. Conclusions Acinetobacter baumannii has a strong resistance to commonly used antimicrobial drugs in clinical practice. It may give priority to amikacin or antibiotics with sulbactam in clinical practice, and may also be combined according to the specific conditions of patients to Anti-drug-resistant strains and the proliferation of nosocomial infections, and pay attention to disinfection and isolation, to prevent cross-infection.