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自制了3种键合型直链淀粉苯基氨基甲酸酯类(苯基氨基甲酸酯IAT、3-氯苯基氨基甲酸酯IAC、3,5-二甲基苯基氨基甲酸酯IAD)手性固定相,比较了3种固定相对6种手性化合物的手性识别能力,同时也将商品柱Chiralcel OD-H、Chiralcel AD-H对6种手性化合物的拆分结果进行了比较。实验结果表明:所合成的键合型手性固定相对样品托儿格碱、2-羟基-3-(2-萘氧基)丙基-2’,3’-二甲基苯基硒醚和戊唑醇表现出更好的手性识别能力,并且直链淀粉衍生物苯环上引入吸电子基团或给电子基团对固定相手性识别能力均有明显的影响。
Three types of bonded amylphenyl carbamates (phenylcarbamate IAT, 3-chlorophenylcarbamate IAC, 3,5-dimethylphenylcarbamate IAD ) Chiral stationary phase. The chiral recognition ability of three chiral stationary phases against six chiral compounds was compared. Chiralcel OD-H and Chiralcel AD-H were also used to compare the resolution of six chiral compounds . The experimental results show that the synthesized chiral stationary phase of the sample is stable against the infiltration of the sample Protoplast, 2-hydroxy-3- (2-naphthyloxy) propyl-2 ’, 3’-dimethylphenylselenyl ether and Tebuconazole showed better ability of chiral recognition, and the introduction of electron-withdrawing groups on the benzene rings of amylose derivatives or the ability of electron-donating groups to recognize the chirality of stationary phase obviously.