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目的探讨柳氮磺胺吡啶（ＳＡＳＰ）治疗大鼠乙酸性溃疡性结肠炎（ＵＣ）时清除氧自由基（ＯＦＲ）的特性．方法ＳＡＳＰ灌胃治疗大鼠乙酸性ＵＣ后，检测肠组织中的超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）含量，评价其炎症指数，并与生理盐水（ＮＳ）治疗对照组比较．结果ＳＡＳＰ组和ＮＳ组ＳＯＤ含量（Ｕ／ｇ）分别为７９９８±３４４１和６３６４±２４５５．ＳＡＳＰ组和ＮＳ组ＭＤＡ含量（ｎｍｏｌ／ｇ）分别为２１５６±２０８、３５２４±４４８．ＮＳ组和ＳＡＳＰ组炎症指数分别为１６５±５１９、６３０±１２５．ＳＡＳＰ组ＳＯＤ含量显著高于ＮＳ组（７９９８±３４４１对６３６４±２４５５，Ｐ＜００１），ＳＡＳＰ组ＭＤＡ含量明显低于ＮＳ组（２１５６±２０８对３５２４±４４８，Ｐ＜００１）．ＮＳ组炎症指数明显高于ＳＡＳＰ组（１６５±５１９对６３０±１２５，Ｐ＜００１）．结论ＳＡＳＰ为氧自由基清除剂，是治疗溃疡性结肠炎的主要机理之一．
Objective To investigate the scavenging oxygen free radical (OFR) of sulfasalazine (SASP) in the treatment of acetic acid ulcerative colitis (UC) in rats. Methods After oral administration of SASP to rats with acetic acid, the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in intestinal tissue were measured and the inflammatory index was evaluated. Compared with NS group, . Results The SOD contents in SASP group and NS group were 7998 ± 3441 and 6364 ± 2455, respectively. The MDA contents (nmol / g) in SASP group and NS group were 2156 ± 208 and 3524 ± 448, respectively. The inflammation index of NS group and SASP group were 165 ± 519 and 630 ± 125, respectively. The SOD level in SASP group was significantly higher than that in NS group (7998 ± 3441 vs 6364 ± 2455, P <001). The MDA content in SASP group was significantly lower than that in NS group (2156 ± 208 For 35 24 ± 4 48, P <0 01). The inflammatory index in NS group was significantly higher than that in SASP group (165 ± 519 vs. 630 ± 125, P <001). Conclusion SASP is an oxygen free radical scavenger, which is one of the main mechanisms for the treatment of ulcerative colitis.