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目的了解血液灌流对维持性血液透析患者血清甲状旁腺素(PTH)的清除效果。方法将70例维持性血液透析患者随机分为两组:血液透析+血液灌流组(HD+HP组)和血液透析组(HD组),HD+HP组接受树脂吸附联合血液透析治疗,HD组接受血液透析治疗,放射免疫法测定血清PTH水平。结果 HD+HP组治疗后患者血PTH从(285.1±211.2)pg/ml降至(120.1±104.2)pg/ml,平均清除率为47.5%,治疗前后比较差异有显著性(P<0.05);HD组治疗后血PTH从(292.2±199.1)pg/ml降至(248.6±100.3)pg/ml,平均清除率为12.9%,治疗前后比较差异无显著性(P>0.05)。结论血液灌流联合血液透析能有效地清除PTH,而血液透析不能有效地清除PTH。
Objective To understand the effect of hemoperfusion on the serum parathyroid hormone (PTH) clearance in maintenance hemodialysis patients. Methods Seventy patients with maintenance hemodialysis were randomly divided into two groups: hemodialysis + hemoperfusion group (HD + HP group) and hemodialysis group (HD group). HD + HP group was treated with resin adsorption combined with hemodialysis, HD group Hemodialysis was performed and serum PTH level was measured by radioimmunoassay. Results The blood PTH level in HD + HP group decreased from (285.1 ± 211.2) pg / ml to (120.1 ± 104.2) pg / ml, and the average clearance rate was 47.5%. There was significant difference between before and after treatment (P <0.05) PTH decreased from (292.2 ± 199.1) pg / ml to (248.6 ± 100.3) pg / ml in HD group after treatment, and the average clearance rate was 12.9%. There was no significant difference between before and after treatment (P> 0.05). Conclusion Hemoperfusion combined with hemodialysis can effectively remove PTH, but hemodialysis can not effectively remove PTH.